nr kat. 41-952-500
Transferrin, Human, Iron- Saturated
Transferrin is an important constituent in
growth medium. It is a glycoprotein but also
known more specifically, as an iron-storage
protein, found in mammalian serum (i.e. a
blood plasma protein). Transferrin receptors,
on the cell surface of actively growing cells,
bind transferrin for iron transport to and
from cells. In humans, it is still the most
dynamically important iron pool relative to
the total iron throughout the body.
Nevertheless, research has shown that the
majority of circulating iron-bound transferrin
is transported to the bone marrow and
incorporated into newly formed red blood cells
or erythrocytes. The other primary storage
depots for stored iron are the liver and
spleen. The sum of all iron-binding sites on
transferrin constitutes the total iron-binding
capacity or TIBC of plasma. When iron-free,
transferring is known as apo-Transferrin and
when iron saturated it is called holo
Transferrin. Traditionally, transferrin has
entered the cell culture domain as a component
of serum and is not a routine component of
most commercially produced basal media.
However, it has gained popularity and it is
often added to classical basal media for the
delivery of iron especially in a serumfree
milieu. As a plasma-derived product, it is
available for cell culture and diagnostic
assays but not for therapeutic use.
Each unit of Biological Industries'
transferrin is pasteurized and heated for 10
Hours @60ºC. It is manufactured under GMP
conditions from Human Blood Plasma sub
Fraction IV-1. It is important to emphasize
that it is for research laboratory or further
manufacturing purposes only. It is not
intended for human use. It is a USA-sourced
and approved product and plasma donors undergo
a rigorous selection process as per FDA
requirements.
Each unit of plasma and each plasma pool has
been tested to be nonreactive for Hepatitis B
Surface Antigen (HBsAg), Antibody to (Human
Immunodeficiency Virus) HIV-I and II, anti-HCV
and Syphilis.
Wielkość opakowania: 500 mg
Produkt dostępny także w opakowaniu 100 mg.
br> Strona producenta: http://www.bioin(...)sp=122
87